Poor eyesight debuff- I had to wear the <glasses> item when I was level 12 or 13. It's a hassle really because I bought the <glasses> item 3 times.
Possible diabetic debuff - I ate a lot of <food> to increase my HP but it turns out that eating a lot of <food> makes you prone to the Diabetic debuff. I am currently increasing my Strength and Agility stats to remove this debuff.
Toribash debuff - no will to live, no hope left in humanity