I agree with Thron, of course being able to predict what you opponent may or may not do is definitely an important part of the skill set you need to be good at TB. Keep in mind also, that many situations you may find yourself in have different reactions that would work in different ways, but each reaction is effective in it's own way.
EXAMPLE: Imagine you're fitting in for a hip throw, but your opponent managed to get out of it by creating space. You could either turn in to him and do a switch drop, or you could turn away from him and do a suplex. Both reactions work in the end.